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BU Scientists Make First Connection Of Severe CTE With Genes

Scientists who assess the degenerative brain disease that bothered Aaron Hernandez, as well as other football players, have long mystified over a fundamental anonymity: Why does CTE, or chronic traumatic encephalopathy, hit few individuals harder than others? A research team at the Boston University School of Medicine recognizes a new hint in comprehending a sickness that has raised worrying queries regarding the long-term threats of playing contact sports.

The genes had been believed of playing a part in CTE, and the research is the foremost to propose a particular cause: a common version of a gene called TMEM106B. The scientist assessed the brains of a small set of individuals diagnosed with CTE after death, which causes an array of emotional and cognitive impairments and has been associated with repetitive gusts to the head. They discovered that those having TMEM106B variant were more prone to have a serious ailment and were 2.5x more expected to develop dementia.

However, to the scientists’ revelation, having this gene variant didn’t make an individual more probable to develop CTE basically. “That result proposes that the environmental exposure to recurring head bangs is the overpowering driver of developing this ailment,” said one the study authors and a neuropathologist from the VA Boston Healthcare System, Dr Thor D. Stein. More directly, Stein and team stated, the research pinpoints the means for future study into the mechanisms at the core of CTE, and that might someday result in treatments.

In another study, scientists have examined the inheritance patterns of about 800 families having 1 or more individuals affected by Tourette syndrome, which is a neuropsychiatric disorder. An international team of researchers, comprising scientists from Uppsala University in Sweden, have found a number of genes that augment the threat of developing Tourette’s. The findings are issued in the Cell Reports journal.